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Therapy with DNA repair inhibitors in early phase clinical trials

DNA repair inhibitor

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p38 MAPK

This was related to the increased option of NADPH for use by furfural reductase, as over expression of glucose 6-phosphate dehydrogenase for the reason that produces NADPH, was found to improve tolerance to furfural 162

November 18, 2021 climat2050

This was related to the increased option of NADPH for use by furfural reductase, as over expression of glucose 6-phosphate dehydrogenase for the reason that

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Epigenetics

The degrees of pSTAT5 were quantified by densitometry and normalized to -Actin (lower panel)

November 16, 2021 climat2050

The degrees of pSTAT5 were quantified by densitometry and normalized to -Actin (lower panel). with KIT-targeting medications (toceranib, masitinib, nilotinib, midostaurin) in NI-1 cells. Bottom

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DNA Ligases

We found that plasma nitrate, nitrite and RXNO levels were not significantly changed by low-dose Ang II or by an infusion of low-dose Ang II + PD123319 (Number 4E)

November 15, 2021 climat2050

We found that plasma nitrate, nitrite and RXNO levels were not significantly changed by low-dose Ang II or by an infusion of low-dose Ang II

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NKCC Cotransporter

The validation cohort received dutasteride, whereas the discovery cohort did not; however, the changes in FFM and muscle mass strength in response to testosterone administration were comparable in the two groups, as well as the findings in the discovery cohort had been confirmed in the validation cohort largely

November 13, 2021 climat2050

The validation cohort received dutasteride, whereas the discovery cohort did not; however, the changes in FFM and muscle mass strength in response to testosterone administration

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mGlu Group III Receptors

These small-molecule chemical substances could also be used to probe the mechanisms of activation and inhibition of the GPCR through testing of wild-type and mutant receptor isoforms

November 12, 2021 climat2050

These small-molecule chemical substances could also be used to probe the mechanisms of activation and inhibition of the GPCR through testing of wild-type and mutant

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Motilin Receptor

IL-33 may activate cells from the innate aswell as the adaptive disease fighting capability via relationship with membrane ST2, which, specifically, is abundantly expressed on the top of T helper 2 (Th2) cells and mast cells [83]

November 9, 2021 climat2050

IL-33 may activate cells from the innate aswell as the adaptive disease fighting capability via relationship with membrane ST2, which, specifically, is abundantly expressed on

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p56lck

Both the percentage of LDs decorated with LC3 (Figure 4G and 4H) and the percentage of autophagic vacuoles containing lipid as cargo (Figure 4G and 4I) were significantly higher in SOCE-deficient cells, suggesting increased lipophagy

November 6, 2021 climat2050

Both the percentage of LDs decorated with LC3 (Figure 4G and 4H) and the percentage of autophagic vacuoles containing lipid as cargo (Figure 4G and

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trpp

Rf 0

November 5, 2021 climat2050

Rf 0.5 SRT 1720 Hydrochloride (Hexane/EtOAc: 8/2). chlorinated derivative 2 being the most potent. Table 2 Results of PHGDH inhibition for compounds 1C11. All experiments

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Other Transcription Factors

Based on the developing evidence, the AR signaling pathway may be turned on in advanced prostate carcinoma constitutively, probably by AR imitating the configuration of ligand-activated AR in the lack of androgen

November 1, 2021 climat2050

Based on the developing evidence, the AR signaling pathway may be turned on in advanced prostate carcinoma constitutively, probably by AR imitating the configuration of

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CCK Receptors

Xylometazoline was the most potent imidazoline agonist, which was between 10- and 100-fold more potent than l-erythro-methoxamine and noradrenaline, respectively (Table 3)

October 31, 2021 climat2050

Xylometazoline was the most potent imidazoline agonist, which was between 10- and 100-fold more potent than l-erythro-methoxamine and noradrenaline, respectively (Table 3). highest concentration used.

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